https://www.breastnexum.com/ Sun, 12 Apr 2026 22:26:45 +0000 MyBB https://www.breastnexum.com/showthread.php?tid=33932 Sun, 23 Nov 2025 09:41:54 +0000 Teddy]]> https://www.breastnexum.com/showthread.php?tid=33932
A snippet from the conclusions:

" In summary, serum estradiol concentration has not been found to be associated with breast-chest difference or Tanner stage in transgender individuals. However, ensuring suppression of testosterone might be an important factor to promote maximal breast development. Limited data are available examining bra cup size or development of the nipple-areolar complex and this requires further study."

In other words, this study hints that for breast development exact Estradiol concentration isn't necessarily as important as Testosterone suppression, as so many others have also indicated.

Any comments?

-Teddy]]>
A snippet from the conclusions:

" In summary, serum estradiol concentration has not been found to be associated with breast-chest difference or Tanner stage in transgender individuals. However, ensuring suppression of testosterone might be an important factor to promote maximal breast development. Limited data are available examining bra cup size or development of the nipple-areolar complex and this requires further study."

In other words, this study hints that for breast development exact Estradiol concentration isn't necessarily as important as Testosterone suppression, as so many others have also indicated.

Any comments?

-Teddy]]> https://www.breastnexum.com/showthread.php?tid=32744 Thu, 07 Aug 2025 22:18:10 +0000 Denisem]]> https://www.breastnexum.com/showthread.php?tid=32744 https://www.breastnexum.com/showthread.php?tid=32576 Thu, 26 Jun 2025 20:48:42 +0000 ScottNBE]]> https://www.breastnexum.com/showthread.php?tid=32576 My chest feels noticeably fuller and incredibly sore and kind of a burning sensation. Not bad just kind of an icy hot feeling. 
I tried it cause it’s so cheap at 7.00 at the store and thinking yeah right but maybe. 

I have gynecomastia prior to beginning NBE last week and have begun taking RR and BO but was curious if lavender oil really does have a reaction like this? My shirts are noticeable tighter and there’s definitely more volume there. And feels like more tissue has grown. But in a weeks time??? I’m curious for those well versed in herbs and such if lavender oil can have this effect so quick or if it may be oils in the lotion causing irritation and inflammation prompting swelling more than genuine growth?]]> My chest feels noticeably fuller and incredibly sore and kind of a burning sensation. Not bad just kind of an icy hot feeling. 
I tried it cause it’s so cheap at 7.00 at the store and thinking yeah right but maybe. 

I have gynecomastia prior to beginning NBE last week and have begun taking RR and BO but was curious if lavender oil really does have a reaction like this? My shirts are noticeable tighter and there’s definitely more volume there. And feels like more tissue has grown. But in a weeks time??? I’m curious for those well versed in herbs and such if lavender oil can have this effect so quick or if it may be oils in the lotion causing irritation and inflammation prompting swelling more than genuine growth?]]> https://www.breastnexum.com/showthread.php?tid=32491 Wed, 21 May 2025 10:03:02 +0000 Moobdood]]> https://www.breastnexum.com/showthread.php?tid=32491 https://www.breastnexum.com/showthread.php?tid=32436 Thu, 01 May 2025 10:13:13 +0000 Sissy venessa]]> https://www.breastnexum.com/showthread.php?tid=32436 https://www.breastnexum.com/showthread.php?tid=32406 Sun, 06 Apr 2025 02:20:48 +0000 thegirl1951]]> https://www.breastnexum.com/showthread.php?tid=32406 I have not noticed much sensitivity increase in the nipples.
Thanks]]> I have not noticed much sensitivity increase in the nipples.
Thanks]]> https://www.breastnexum.com/showthread.php?tid=32341 Wed, 19 Feb 2025 23:28:12 +0000 SensualTiffany]]> https://www.breastnexum.com/showthread.php?tid=32341
Based on a quick request, I whipped out a hybrid hypnosis file.  It's been something that I have been doing for quite some time and I am able to develop both audio and video hypnosis.  I find the audio to be most effective.   

A technique I started recently is to use an effective, established hypnotist to provide the Induction and then I go into other hypnosis files that I have edited accordingly or have developed from scratch.  The one linked here was developed from scratch.  It is very rough and was produced quickly, but I thought I'd ask for some input before proceeding.

If it is something that you'd be interested in having me develop fully, I am all for input.  PMs are best (especially if it's something best shared in private).  I would remove the Name (Tiffany) from the file and make something generic in nature.  There are other effects that can be brought it, but I'd like to hear from you before spending a lot more time.  

It's meant to be listened to on decent headphones and future edits will make more of an impact as the sound moves around you.  Enjoy:

Soundgasm File

Let me know.

Cheers,

Tiffany]]>
Based on a quick request, I whipped out a hybrid hypnosis file.  It's been something that I have been doing for quite some time and I am able to develop both audio and video hypnosis.  I find the audio to be most effective.   

A technique I started recently is to use an effective, established hypnotist to provide the Induction and then I go into other hypnosis files that I have edited accordingly or have developed from scratch.  The one linked here was developed from scratch.  It is very rough and was produced quickly, but I thought I'd ask for some input before proceeding.

If it is something that you'd be interested in having me develop fully, I am all for input.  PMs are best (especially if it's something best shared in private).  I would remove the Name (Tiffany) from the file and make something generic in nature.  There are other effects that can be brought it, but I'd like to hear from you before spending a lot more time.  

It's meant to be listened to on decent headphones and future edits will make more of an impact as the sound moves around you.  Enjoy:

Soundgasm File

Let me know.

Cheers,

Tiffany]]> https://www.breastnexum.com/showthread.php?tid=32271 Sat, 11 Jan 2025 11:29:42 +0000 Moobdood]]> https://www.breastnexum.com/showthread.php?tid=32271 https://www.breastnexum.com/showthread.php?tid=32114 Sat, 21 Sep 2024 20:43:05 +0000 Stevenator_]]> https://www.breastnexum.com/showthread.php?tid=32114
Granted, this is information that's been covered extensively here on BN, but it's also exciting to see more eyes on her research.

Lotus has shared with us the science of breast growth for many, many years here on BN, to which we all should be indebted to her for her relentless quest of sharing her research.

https://www.reddit.com/r/NaturalBreastGrowth/s/DP1P7psmWq]]>
Granted, this is information that's been covered extensively here on BN, but it's also exciting to see more eyes on her research.

Lotus has shared with us the science of breast growth for many, many years here on BN, to which we all should be indebted to her for her relentless quest of sharing her research.

https://www.reddit.com/r/NaturalBreastGrowth/s/DP1P7psmWq]]> https://www.breastnexum.com/showthread.php?tid=32106 Sun, 15 Sep 2024 13:40:49 +0000 Isabela]]> https://www.breastnexum.com/showthread.php?tid=32106 This could be herbal stuff like pueraria, fenugreek.. etc bovine ovary or mammary crushed pills, or pharmaceutical products like bicalutamide, contraceptive pills or else.. then incorporate this a transcutaneous vehicle, gel or lotion to get it transdermal
Does anyone is involved in this ?..
Thanks]]> This could be herbal stuff like pueraria, fenugreek.. etc bovine ovary or mammary crushed pills, or pharmaceutical products like bicalutamide, contraceptive pills or else.. then incorporate this a transcutaneous vehicle, gel or lotion to get it transdermal
Does anyone is involved in this ?..
Thanks]]> https://www.breastnexum.com/showthread.php?tid=32098 Wed, 11 Sep 2024 03:22:11 +0000 Lotus]]> https://www.breastnexum.com/showthread.php?tid=32098
Estrogel/Estradiol increases the breast size by way of elongation. I'm against cycling progesterone (P4) more than every other day. Essentially you lose progress by going from 2 weeks on P4 to 2 weeks off. As you can see by the amount of information being posted... I put a lot of time into gathering research to share why having a topical cream protocol. Even if you think you stalled, I uncovered research that states T.E.B.s (terminal end buds) have a reserve (15-20%) that has yet to be used. I believe in that statement because I saw an increase of 3-4 inches by using my program.

DHEA for Topical Application 

DHEA activates estrogen receptors. Further information identified how DHEA and its metabolites are synthesized by aromatase… That's a big discovery in my book, now I'm thinking that the combination(s) of DHEA may even stimulate tissue repair in the breast epithelial cells and T.E.B’s (aka- terminal end buds/terminal … or breast buds). 

The conversion of DHEA by aromatase to estriol and subsequently estradiol as an essential prerequisite for DHEA's impact upon in vivo healing and inflammation.

DHEA acts through the classical estrogen receptors (ER) to modulate repair.

DHEA modulates macrophage pro-inflammatory cytokine expression, and reducing inflammation helps better breast growth.

DHEA dampens the local inflammatory response and reduces the tissue levels of a number of pro-inflammatory cytokines. 

DHEA influenced the progressive dermal ischemia occurring following thermal injury to the skin, possible via a non-ER/AR mechanism. We show that DHEA can accelerate wound repair in an impaired model of healing secondary to estrogen-depletion, which mimics age-related healing (Ashcroft et al., 1997a, Ashcroft et al., 1997b

(Ischemia or ischaemia) is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).[3][4] Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue, i.e., hypoxia and microvascular dysfunction.)

Progressive ischemia and necrosis of the skin following thermal injury are reduced by postburn administration of the steroid hormone dehydroepiandrosterone (DHEA)

Findings showed that DHEA increased the antioxidant enzyme activity, decreased ROS generation, and inhibited apoptosis in H2O2-treated cells.

The protective effect of DHEA on BRL-3A cells was mainly associated with PI3K/Akt signaling pathways, rather than MAPK signaling pathways.

The decrease in circulating DHEA levels is associated with multiple metabolic consequences, including autoimmune diseases, aberrations in lipid metabolism, type 2 diabetes, and oxidative stress-related diseases. 

Recently, DHEA was reported to exhibit antioxidative effects under conditions of acute as well as chronic oxidative stress [10–12], and these antioxidant effects have been confirmed through in vivo [13, 14] and in vitro [15] experiments, including our recent study in which DHEA treatment was found to protect various types of cells against oxidative damage

PI3K/p-AKT pathways seem to be closely involved with these protective effects of DHEA on the liver cells.
https://www.hindawi.com/journals/omcl/2019/2985956/

The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating cell growth, metabolism, survival, and angiogenesis. 
https://en.m.wikipedia.org/wiki/Angiogenesis

10 months ago I began reviewing my posts on DHEA and other research I had on it. I wanted to create a topical application program focusing on using HRT hormones and available products to assist in that breast growing program. I can report the combination of DHEA + P4 (micronized progesterone) added 3 inches in new growth in 3 months for myself. I'm listing 3 posts for discussion purposes… please note: it's a long post. Here's a few quotes I'd like to bring attention to. Bio-labs E1/E2, P4, and 17b applications. 

• application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth… "boob growth". 

• Supplemental DHEA raises estrogen in men and postmenopausal women

• breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size but it completely reversed the breast atrophy

• DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures.

• DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland.

• Estradiol treatment induced an increased number of ducts (d), accompanied by the presence of alveolar units (a) and small lobules.

• A marked increase in the amount of lobuloalveolar tissue (l) and in the secretory activity of the acinar cells accompanied by accumulation of secretory material (s) in the duct lumen (d) were observed after DHEA administration (F)

• DHEA (5%) in ethanol:olive oil (1:2) was topically applied to the buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin.

• To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo.

• In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness

Dehydroepiandrosterone (DHEA) is the principal human C-19 steroid. DHEA has very low androgenic potency, but serves as the major direct or indirect precursor for most sex steroids. DHEA is secreted by the adrenal gland and production is at least partly controlled by adrenocorticotropic hormone (ACTH). The bulk of DHEA is secreted as a 3-sulfo conjugate dehydroepiandrosterone sulfate (DHEAS). Both hormones are albumin bound, but DHEAS binding is much tighter. As a result, circulating concentrations of DHEAS are much higher (>100-fold) compared to DHEA. In most clinical situations, DHEA and DHEAS results can be used interchangeably. In gonads and several other tissues, most notably skin, steroid sulfatases can convert DHEAS back to DHEA, which can then be metabolized to stronger androgens and to estrogens.

DHEA is C-19 steroid (androgen) but has a very low potency Supplemental DHEA raises estrogen in men and postmenopausal women. (can also raise androgens (DHT) if some experienced users know how much to use. DHEA applied topically helps restore breast atrophy in an animal study (see below). I found this in another forum, and it describes an animal study using a topical application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth… boob growth. The author (haidut, smart fella btw) suggests a 15mg significantly increases all estrogens. 

The breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size, but it completely reversed the breast atrophy and other negative tissue changes seen in ovariectomized animals (a rodent model of menopause).

From the study,
DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures. In addition, epithelial cell hypertrophy and a marked stimulation of secretory activity were seen, these effects being accompanied by the accumulation of clear and eosinophilic vacuoles in the cytoplasm of the acinar cells. - 

DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland. 
https://pubmed.ncbi.nlm.nih.gov/9449650/

Mammary gland histology in (A) intact control, (B) OVX control, and OVX rats treated with © MPA microspheres, (D) estradiol implants, (E) DHT implants, (F) DHEA, 30 mg, cutaneous application, twice daily, on an area of 3 × 3 cm of dorsal skin, (G) DHEA, 30 mg, cutaneous application, twice daily + FLU, 7.5 mg, sc, twice daily and (H) DHEA, 30 mg, cutaneous application, twice daily + EM-800, 250 μg, orally, once daily. An increase in the number of alveolar units (a) was observed in OVX animals treated with MPA © and DHT (E) with the formation of small primitive lobules (l) after DHT administration (E). Estradiol treatment induced an increased number of ducts (d), accompanied by the presence of alveolar units (a) and small lobules (l), without evidence of secretory activity (D). A marked increase in the amount of lobuloalveolar tissue (l) and in the secretory activity of the acinar cells accompanied by accumulation of secretory material (s) in the duct lumen (d) were observed after DHEA administration (F). The stimulatory effect of DHEA on the mammary gland was completely blocked by simultaneous treatment with FLU (G), whereas no significant histological change was seen after the addition of EM-800 to DHEA compared with DHEA alone (H). Compare with intact (A) and OVX (B) controls. Hematoxylin-eosin, magnification ×200(d, ducts; a, alveoli, l, lobules).

DHEA, 30 mg, cutaneous application, twice daily + FLU, 7.5 mg, sc, twice daily and (E) DHEA, 30 mg, cutaneous application, twice daily + EM-800, 250 μg, orally, once daily.

Two studies, similar effects. In any event, DHEA looks like it can build a bigger butt, and… 
Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.
Son ED1, Lee JY, Lee S, Kim MS, Lee BG, Chang IS, Chung JH.
Author information

* 1 Amorepacific Corp/R&D Center, Gyeonggi-do, Korea.
Abstract
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo. In addition, metalloproteinase (MMP-1 protein levels were reduced by topical 17beta-estradiol. The expressions of TGF-beta1, TGF-beta type II receptor, and Sma and Mad related (Smad)3 were increased by topical 17 beta-estradiol in aged human skin, and TGF-beta1 neutralizing antibody inhibited 17beta-estradiol-induced procollagen synthesis in cultured fibroblasts. We also found that the expressions of tropoelastin and fibrillin-1 mRNA and protein and elastic fibers in aged skin were also increased by topical 17beta-estradiol Topical 17beta-estradiol also increased keratinocyte proliferation and the epidermal thickness in aged human skin. We also observed the same effects of topical 17beta-estradiol in young skin. In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness.
PMID: 15955089 [PubMed - indexed for MEDLINE]

Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin.[/b]
Shin MH1, Rhie GE, Park CH, Kim KH, Cho KH, Eun HC, Chung JH.
Author information

* 1Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28 Yungon-dong, Chongno-Gu, Seoul 110-744, Korea.
Abstract
Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced human adrenal steroids to be reduced with age. DHEA may be related to the process of skin aging through the regulation and degradation of extracellular matrix protein. In this study, we demonstrate that DHEA can increase procollagen synthesis and inhibit collagen degradation by decreasing matrix metalloproteinases (MMP)-1 synthesis and increasing tissue inhibitor of matrix metalloprotease (TIMP-1) production in cultured dermal fibroblasts. DHEA was found to inhibit ultraviolet (UV)-induced MMP-1 production and the UV-induced decrease of procollagen synthesis, probably due to the inhibition of UV-induced AP-1 activity. DHEA (5%) in ethanol:olive oil (1:2) was topically applied to buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin. On the other hand, topical DHEA significantly decreased the basal expression of MMP-1 mRNA and protein, but increased the expression of TIMP-1 protein in aged skin. We also found that DHEA induced the expressions of transforming growth factor-beta1 and connective tissue growth factor mRNA in cultured fibroblasts and aged skin, which may play a role in the DHEA-induced changes of procollagen and MMP-1 expression. Our results suggest the possibility of using DHEA as an anti-skin aging agent.]]>
Estrogel/Estradiol increases the breast size by way of elongation. I'm against cycling progesterone (P4) more than every other day. Essentially you lose progress by going from 2 weeks on P4 to 2 weeks off. As you can see by the amount of information being posted... I put a lot of time into gathering research to share why having a topical cream protocol. Even if you think you stalled, I uncovered research that states T.E.B.s (terminal end buds) have a reserve (15-20%) that has yet to be used. I believe in that statement because I saw an increase of 3-4 inches by using my program.

DHEA for Topical Application 

DHEA activates estrogen receptors. Further information identified how DHEA and its metabolites are synthesized by aromatase… That's a big discovery in my book, now I'm thinking that the combination(s) of DHEA may even stimulate tissue repair in the breast epithelial cells and T.E.B’s (aka- terminal end buds/terminal … or breast buds). 

The conversion of DHEA by aromatase to estriol and subsequently estradiol as an essential prerequisite for DHEA's impact upon in vivo healing and inflammation.

DHEA acts through the classical estrogen receptors (ER) to modulate repair.

DHEA modulates macrophage pro-inflammatory cytokine expression, and reducing inflammation helps better breast growth.

DHEA dampens the local inflammatory response and reduces the tissue levels of a number of pro-inflammatory cytokines. 

DHEA influenced the progressive dermal ischemia occurring following thermal injury to the skin, possible via a non-ER/AR mechanism. We show that DHEA can accelerate wound repair in an impaired model of healing secondary to estrogen-depletion, which mimics age-related healing (Ashcroft et al., 1997a, Ashcroft et al., 1997b

(Ischemia or ischaemia) is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).[3][4] Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue, i.e., hypoxia and microvascular dysfunction.)

Progressive ischemia and necrosis of the skin following thermal injury are reduced by postburn administration of the steroid hormone dehydroepiandrosterone (DHEA)

Findings showed that DHEA increased the antioxidant enzyme activity, decreased ROS generation, and inhibited apoptosis in H2O2-treated cells.

The protective effect of DHEA on BRL-3A cells was mainly associated with PI3K/Akt signaling pathways, rather than MAPK signaling pathways.

The decrease in circulating DHEA levels is associated with multiple metabolic consequences, including autoimmune diseases, aberrations in lipid metabolism, type 2 diabetes, and oxidative stress-related diseases. 

Recently, DHEA was reported to exhibit antioxidative effects under conditions of acute as well as chronic oxidative stress [10–12], and these antioxidant effects have been confirmed through in vivo [13, 14] and in vitro [15] experiments, including our recent study in which DHEA treatment was found to protect various types of cells against oxidative damage

PI3K/p-AKT pathways seem to be closely involved with these protective effects of DHEA on the liver cells.
https://www.hindawi.com/journals/omcl/2019/2985956/

The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating cell growth, metabolism, survival, and angiogenesis. 
https://en.m.wikipedia.org/wiki/Angiogenesis

10 months ago I began reviewing my posts on DHEA and other research I had on it. I wanted to create a topical application program focusing on using HRT hormones and available products to assist in that breast growing program. I can report the combination of DHEA + P4 (micronized progesterone) added 3 inches in new growth in 3 months for myself. I'm listing 3 posts for discussion purposes… please note: it's a long post. Here's a few quotes I'd like to bring attention to. Bio-labs E1/E2, P4, and 17b applications. 

• application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth… "boob growth". 

• Supplemental DHEA raises estrogen in men and postmenopausal women

• breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size but it completely reversed the breast atrophy

• DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures.

• DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland.

• Estradiol treatment induced an increased number of ducts (d), accompanied by the presence of alveolar units (a) and small lobules.

• A marked increase in the amount of lobuloalveolar tissue (l) and in the secretory activity of the acinar cells accompanied by accumulation of secretory material (s) in the duct lumen (d) were observed after DHEA administration (F)

• DHEA (5%) in ethanol:olive oil (1:2) was topically applied to the buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin.

• To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo.

• In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness

Dehydroepiandrosterone (DHEA) is the principal human C-19 steroid. DHEA has very low androgenic potency, but serves as the major direct or indirect precursor for most sex steroids. DHEA is secreted by the adrenal gland and production is at least partly controlled by adrenocorticotropic hormone (ACTH). The bulk of DHEA is secreted as a 3-sulfo conjugate dehydroepiandrosterone sulfate (DHEAS). Both hormones are albumin bound, but DHEAS binding is much tighter. As a result, circulating concentrations of DHEAS are much higher (>100-fold) compared to DHEA. In most clinical situations, DHEA and DHEAS results can be used interchangeably. In gonads and several other tissues, most notably skin, steroid sulfatases can convert DHEAS back to DHEA, which can then be metabolized to stronger androgens and to estrogens.

DHEA is C-19 steroid (androgen) but has a very low potency Supplemental DHEA raises estrogen in men and postmenopausal women. (can also raise androgens (DHT) if some experienced users know how much to use. DHEA applied topically helps restore breast atrophy in an animal study (see below). I found this in another forum, and it describes an animal study using a topical application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth… boob growth. The author (haidut, smart fella btw) suggests a 15mg significantly increases all estrogens. 

The breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size, but it completely reversed the breast atrophy and other negative tissue changes seen in ovariectomized animals (a rodent model of menopause).

From the study,
DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures. In addition, epithelial cell hypertrophy and a marked stimulation of secretory activity were seen, these effects being accompanied by the accumulation of clear and eosinophilic vacuoles in the cytoplasm of the acinar cells. - 

DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland. 
https://pubmed.ncbi.nlm.nih.gov/9449650/

Mammary gland histology in (A) intact control, (B) OVX control, and OVX rats treated with © MPA microspheres, (D) estradiol implants, (E) DHT implants, (F) DHEA, 30 mg, cutaneous application, twice daily, on an area of 3 × 3 cm of dorsal skin, (G) DHEA, 30 mg, cutaneous application, twice daily + FLU, 7.5 mg, sc, twice daily and (H) DHEA, 30 mg, cutaneous application, twice daily + EM-800, 250 μg, orally, once daily. An increase in the number of alveolar units (a) was observed in OVX animals treated with MPA © and DHT (E) with the formation of small primitive lobules (l) after DHT administration (E). Estradiol treatment induced an increased number of ducts (d), accompanied by the presence of alveolar units (a) and small lobules (l), without evidence of secretory activity (D). A marked increase in the amount of lobuloalveolar tissue (l) and in the secretory activity of the acinar cells accompanied by accumulation of secretory material (s) in the duct lumen (d) were observed after DHEA administration (F). The stimulatory effect of DHEA on the mammary gland was completely blocked by simultaneous treatment with FLU (G), whereas no significant histological change was seen after the addition of EM-800 to DHEA compared with DHEA alone (H). Compare with intact (A) and OVX (B) controls. Hematoxylin-eosin, magnification ×200(d, ducts; a, alveoli, l, lobules).

DHEA, 30 mg, cutaneous application, twice daily + FLU, 7.5 mg, sc, twice daily and (E) DHEA, 30 mg, cutaneous application, twice daily + EM-800, 250 μg, orally, once daily.

Two studies, similar effects. In any event, DHEA looks like it can build a bigger butt, and… 
Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.
Son ED1, Lee JY, Lee S, Kim MS, Lee BG, Chang IS, Chung JH.
Author information

* 1 Amorepacific Corp/R&D Center, Gyeonggi-do, Korea.
Abstract
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo. In addition, metalloproteinase (MMP-1 protein levels were reduced by topical 17beta-estradiol. The expressions of TGF-beta1, TGF-beta type II receptor, and Sma and Mad related (Smad)3 were increased by topical 17 beta-estradiol in aged human skin, and TGF-beta1 neutralizing antibody inhibited 17beta-estradiol-induced procollagen synthesis in cultured fibroblasts. We also found that the expressions of tropoelastin and fibrillin-1 mRNA and protein and elastic fibers in aged skin were also increased by topical 17beta-estradiol Topical 17beta-estradiol also increased keratinocyte proliferation and the epidermal thickness in aged human skin. We also observed the same effects of topical 17beta-estradiol in young skin. In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness.
PMID: 15955089 [PubMed - indexed for MEDLINE]

Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin.[/b]
Shin MH1, Rhie GE, Park CH, Kim KH, Cho KH, Eun HC, Chung JH.
Author information

* 1Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28 Yungon-dong, Chongno-Gu, Seoul 110-744, Korea.
Abstract
Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced human adrenal steroids to be reduced with age. DHEA may be related to the process of skin aging through the regulation and degradation of extracellular matrix protein. In this study, we demonstrate that DHEA can increase procollagen synthesis and inhibit collagen degradation by decreasing matrix metalloproteinases (MMP)-1 synthesis and increasing tissue inhibitor of matrix metalloprotease (TIMP-1) production in cultured dermal fibroblasts. DHEA was found to inhibit ultraviolet (UV)-induced MMP-1 production and the UV-induced decrease of procollagen synthesis, probably due to the inhibition of UV-induced AP-1 activity. DHEA (5%) in ethanol:olive oil (1:2) was topically applied to buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin. On the other hand, topical DHEA significantly decreased the basal expression of MMP-1 mRNA and protein, but increased the expression of TIMP-1 protein in aged skin. We also found that DHEA induced the expressions of transforming growth factor-beta1 and connective tissue growth factor mRNA in cultured fibroblasts and aged skin, which may play a role in the DHEA-induced changes of procollagen and MMP-1 expression. Our results suggest the possibility of using DHEA as an anti-skin aging agent.]]> https://www.breastnexum.com/showthread.php?tid=31753 Thu, 07 Mar 2024 23:50:16 +0000 patrick14]]> https://www.breastnexum.com/showthread.php?tid=31753
I am trying to increase their size further and am looking for a simple starter regimen - in terms of herbal pills -where I could start off with 2 or 3 supplements.  I'm also in search of the name of a estrogen cream to massage my breast with.  Can someone please give me some ideas of where to start?]]>
I am trying to increase their size further and am looking for a simple starter regimen - in terms of herbal pills -where I could start off with 2 or 3 supplements.  I'm also in search of the name of a estrogen cream to massage my breast with.  Can someone please give me some ideas of where to start?]]> https://www.breastnexum.com/showthread.php?tid=31722 Fri, 16 Feb 2024 16:07:45 +0000 clau78]]> https://www.breastnexum.com/showthread.php?tid=31722 HI,

I signed up specifically to inform everyone, in the past I had published and occasionally frequented the forum but I lost previous contacts.

I'm growing up using tree oil...I use essential oil and put 2-3 drops on each breast, then massage with a few drops of warm or hot water until absorbed, 1 once a day, better in the evening before going to bed, it is likely to have more effect on people with low testosterone levels, obese or over 40 years old, I am continuing and after 15 days I have had a noticeable growth, it seems that the area in question accumulates fat and fills it, it is important to massage laterally, towards the armpits, and in fact that is where the breast grows the most and not in the center, where it should be massaged anyway, I hope I have been useful to someone.
HI]]> HI,

I signed up specifically to inform everyone, in the past I had published and occasionally frequented the forum but I lost previous contacts.

I'm growing up using tree oil...I use essential oil and put 2-3 drops on each breast, then massage with a few drops of warm or hot water until absorbed, 1 once a day, better in the evening before going to bed, it is likely to have more effect on people with low testosterone levels, obese or over 40 years old, I am continuing and after 15 days I have had a noticeable growth, it seems that the area in question accumulates fat and fills it, it is important to massage laterally, towards the armpits, and in fact that is where the breast grows the most and not in the center, where it should be massaged anyway, I hope I have been useful to someone.
HI]]> https://www.breastnexum.com/showthread.php?tid=31553 Thu, 23 Nov 2023 16:29:50 +0000 Elessar72655]]> https://www.breastnexum.com/showthread.php?tid=31553 https://www.breastnexum.com/showthread.php?tid=31380 Sun, 09 Jul 2023 17:03:13 +0000 Boobynewbie]]> https://www.breastnexum.com/showthread.php?tid=31380