07-03-2026, 07:51 PM
I know, weird post for this forum but hopefully this is the best spot because of your friendliness to gender spectrum stuff and also individuals' research on glandulars and the endocrine system.
I’m curious if anyone here has experience using testicular glandular supplements during hormonal recovery or re-masculinization.
Background: I was on estrogen for about 1.5 years and have now been off for around a year. During that time I had fairly typical feminizing changes (breast development, softer skin, body fat redistribution, etc.).
As part of trying to move back toward a more masculine baseline, I started experimenting with freeze-dried powdered bull testicle (from brand "Heart and Soil"--It's expensive at the recommended dose but right now I've only been taking 1/3 of the manufacturer-recommended dose so it works for my budget). I know these supplements are controversial and the evidence base seems thin, so I’m mostly trying to compare experiences.
Some things I’ve personally noticed since stopping estrogen and taking the glandular:
* Testicle size has returned close to what it was before estrogen.
* My breasts have shrunk from roughly a B/C cup down to a small A. There is still noticeable nipple size and some remaining tissue.
* Strength and muscle are coming back, especially in my legs and thighs.
* Fat loss from my lower body has made my legs feel and look noticeably “harder” again.
* Skin is still softer and paler than it used to be.
The difficult part is separating cause and effect. I don’t know how much of this is simply natural hormonal rebound after stopping estrogen and how much might be related to the supplement.
My question is whether testicular glandulars are thought to have any real endocrine signaling effect in the body, similar to how bovine ovary glandular supplements are sometimes claimed to influence feminization.
Is there any science behind the idea that consuming freeze-dried reproductive gland tissue could influence the endocrine system, or is it basically just protein/nutrients once digested?
Interested in hearing experiences or any research people know about.
I’m curious if anyone here has experience using testicular glandular supplements during hormonal recovery or re-masculinization.
Background: I was on estrogen for about 1.5 years and have now been off for around a year. During that time I had fairly typical feminizing changes (breast development, softer skin, body fat redistribution, etc.).
As part of trying to move back toward a more masculine baseline, I started experimenting with freeze-dried powdered bull testicle (from brand "Heart and Soil"--It's expensive at the recommended dose but right now I've only been taking 1/3 of the manufacturer-recommended dose so it works for my budget). I know these supplements are controversial and the evidence base seems thin, so I’m mostly trying to compare experiences.
Some things I’ve personally noticed since stopping estrogen and taking the glandular:
* Testicle size has returned close to what it was before estrogen.
* My breasts have shrunk from roughly a B/C cup down to a small A. There is still noticeable nipple size and some remaining tissue.
* Strength and muscle are coming back, especially in my legs and thighs.
* Fat loss from my lower body has made my legs feel and look noticeably “harder” again.
* Skin is still softer and paler than it used to be.
The difficult part is separating cause and effect. I don’t know how much of this is simply natural hormonal rebound after stopping estrogen and how much might be related to the supplement.
My question is whether testicular glandulars are thought to have any real endocrine signaling effect in the body, similar to how bovine ovary glandular supplements are sometimes claimed to influence feminization.
Is there any science behind the idea that consuming freeze-dried reproductive gland tissue could influence the endocrine system, or is it basically just protein/nutrients once digested?
Interested in hearing experiences or any research people know about.